Written by Steve Theunissen | ISSA: CPT & Fitness Nutrition
Fact checked by Robert Iafelice, MS, RD, LDN
FACT CHECKED
We adhere to a strict methodology when reviewing products. We strive to deliver you an unbiased opinion on products and services so that you're able to make an informed decision. Learn More
We may earn a commission on purchases made through links on this page at no cost to you. Learn More
Introducing a new product into an already crowded market with its established market leaders is a daunting task. To create an impression, you've got to match effective marketing with quality ingredients that are dosed to produce results.
FlexAgain is a relative newcomer to the joint health market that seems to have gotten both of those elements right. It's getting some great customer reviews, leading to a lot of online buzz.
So, is FlexAgain as good as it seems? Let's do a deep dive to find out.
Table Of Contents
- What Is FlexAgain?
- FlexAgain Review: Pass or Fail?
- 11 FlexAgain Ingredients
- FlexAgain Claimed Benefits
- FlexAgain Side Effects
- When To Take FlexAgain
- Real Customer Reviews Of FlexAgain
- FlexAgain Alternatives
- FAQs
FlexAgain is the most comprehensive joint health supplement on our list, with a whopping 11 fully dosed ingredients designed to support joint mobility, flexibility and overall health it’s a fantastic choice...
What Is FlexAgain?
Flex Again is a joint health supplement that was created by the British company FlexAgain. While this, their flagship product, has been around for a while in the United Kingdom, it was only introduced onto the US market at the end of 2022. According to the press release accompanying that launch, FlexAgain was rated the best over-the-counter joint supplement in the UK.
According to Dr. Mark Watson from Center TRT, Flex Again sets itself apart from the competition because 'all of the ingredients in there have been shown to work in clinical or double-blind trials, and for the most part FlexAgain is correctly dosed for the purpose of treating joint pain or OA. Like most supplements, it's not a perfect solution, but it will definitely help more than anything else I've seen on the over-the-counter joint supplement market.'
FlexAgain is priced at $69.47 on the official website. It can also be purchased on Amazon. The daily recommended dosage is four capsules.
FlexAgain Review: Pass Or Fail?
FlexAgain isn't like most joint supplements. Go to the official website, and you won't see slick advertising, glossy images, and over-the-top promises. In fact, the company behind the product is refreshingly honest. They don't promise the world. What they do do is deliver a supplement packed with 11 research-supported ingredients and clinically sound dosages. They also provide excellent customer service if current buyer feedback is anything to go by.
Standout ingredients in the FlexAgain supplement are Omega-3 fatty acids, resveratrol, boswellic acids, and turmeric extract. The product is competitively priced and comes with a 90-day money-back guarantee. It's a refreshing addition to the joint supplement market that looks set to give the current market leaders a run for their money.
Overall Verdict: PASS
Pros
- 11 research-supported ingredients
- Well dosed
- Excellent customer service
Cons
- Some ingredients may interfere with blood thinner medications at high doses
11 FlexAgain Ingredients
Flex Again joint supplement packs a lot of nutritional power into its formula, with some pretty impressive dosages to go with it (that's why it requires four capsules per dose). Here's the breakdown:
1) Omega-3s - 1100mg
Omega-3 fatty acids are a type of polyunsaturated fats that are essential for optimum health. They have potent anti-inflammatory properties that can help reduce joint health. The two key fatty acids are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), commonly found in fatty fish.
Omega-3s may be able to reduce joint pain from osteoarthritis and rheumatoid arthritis (1). The dosage of 1100 mg is higher than you find in many joint health supplements and is in accordance with the dosages used in clinical trials.
2) Vitamin D - 15mcg
A lack of Vitamin D has been shown to increase joint pain, so including it in a joint supplement is a no-brainer (2).
3) Vitamin K2 - 70mcg
Research shows that maintaining healthy levels of Vitamin K2 can offset the symptoms of osteoarthritis (3). The dosage provided here seems to be about right.
4) Ginger and Blue Galangal - 250mg
Ginger is a potent anti-inflammatory, helping to reduce joint pain and support joint health. However, it needs to be dosed at a level too high to fit into a capsulized supplement (around 3000 mg). FlexAgain has addressed this problem by pairing it with Blue Galangal extract. This allows it to be packed twelve times more densely. As a result, the 250 mg dose used here has been shown to be equivalent to 3000 mg of stand-alone ginger (4).
5) Bromelain - 100mg
Bromelain is an extract from the pineapple that has been shown to have anti-inflammatory, as well as analgesic (pain relieving) properties. A 2004 review showed that bromelain may be as effective as NSAIDs in these areas (5).
6) Curcumin Extract - 500mg
Curcumin extract comes from the herb turmeric. It is well known for its anti-inflammatory properties, being shown to be able to actually block several inflammatory enzymes and cytokines (6).
The 500mg dosage aligns with the amounts used in clinical trials.
7) Resveratrol - 100mg
Resveratrol, an extract from grapes, is another compound with strong anti-inflammatory properties. It also has anti-oxidant abilities that help offset the free radical damage from oxidative stress that can cause joint pain. It may also help to offset cartilage breakdown (7).
8) MSM - 50mg
Methylsulfonylmethane (MSM) is a sulfur compound found in plants and animals that provides a source of dietary sulfur. This is needed for connective tissue health, such as collagen. In one study, MSM was shown to improve symptoms of osteoarthritic knee pain (4).
9) Glucosamine HCL - 400mg
Glucosamine is a compound found in the fluid that surrounds our joints. It is essential for cartilage maintenance and repair. Natural production of glucosamine slows as we age, making supplementing with it a good idea. The recommended dosage is between 500mg and 3g daily, so the 400mg provided here is down a little from what we'd like to have seen.
10) Chondroitin - 250mg
There is research to show that the beneficial effects of glucosamine are enhanced when coupled with chondroitin. That is why FlexAgain has added it to this formula.
11) Boswellic Acid - 100mg
Boswellic acids are potent anti-inflammatories with the ability to block molecules, such as free radicals, that attack joints and cartilage. The 100mg dose was the same as in a 2020 study, which showed significant improvement in joint function (8).
FlexAgain Claimed Benefits
FlexAgain is one of those rare promoters who don't claim their product is a 'magic pill' to cure all your joint health problems. Instead, they suggest that it will probably help with the following:
1) Reduces Joint Pain
FlexAgain is packed with ingredients that have been shown to reduce inflammation, which is a major cause of joint and muscle pain. Other ingredients, like glucosamine, promote joint health and may lessen discomfort brought on by cartilage damage. Due to its anti-inflammatory qualities, MSM may help lessen joint pain and stiffness, enhancing mobility and promoting overall joint health.
2) Reduces Stiffness
The curcumin extract in FlexAgain has anti-inflammatory properties that may reduce joint stiffness. Boswellic acids also contribute to easing joint stiffness, enabling more comfortable mobility. Glucosamine enhances joint flexibility by assisting in preserving and repairing cartilage, which can lessen stiffness and alleviate joint pain. MSM also has anti-inflammatory properties that may help lessen joint stiffness, improving joint function.
3) Supports Long-Term Joint Health
The 1100mg of omega-3 fatty acids in FlexAgain help reduce inflammation and preserve joint health, promoting the long-term health of the body's joints. Ginger and curcumin also have anti-inflammatory characteristics that can help gradually lessen joint inflammation and enhance joint health.
FlexAgain Side Effects
When used according to the recommended dosage, FlexAgain is safe for most users. Individual reactions, however, can differ, and there is a chance for adverse reactions or drug interactions, mainly if used in excess or in conjunction with specific prescriptions. Here are a few of the potential side effects of some specific ingredients:
-
Boswellic acid: These acids may infrequently bring on minor gastrointestinal issues like diarrhea or upset stomach.
-
Glucosamine: Mild digestive side effects, including gas, bloating, and diarrhea, are potential adverse effects. Blood-thinning medicines, among others, may interact negatively with glucosamine.
-
Resveratrol: Most people tolerate resveratrol well, although some may experience gastric discomfort from large dosages. Resveratrol may also interact adversely with blood thinner medications.
-
Curcumin: Blood-thinning medications and liver-damaging pharmaceuticals may both interact with curcumin.
-
Ginger: Ginger is typically harmless, but for some people, it can have modest side effects on the digestive system, such as heartburn or stomach trouble. It may also interfere with blood-thinning medicines.
-
Omega-3 fatty acids: A fishy aftertaste, burping, or slight digestive discomfort are all common side effects of omega-3 pills. Again, supplements high in omega-3 may interact negatively with blood-thinning drugs.
When To Take FlexAgain
There is no recommended time of day to take FlexAgain on the bottle or the official website. Many people take it first thing in the morning as part of their wake-up routine. If you experience digestive problems, try taking it with food, as this will help with digestion.
How To Take FlexAgain
Take four capsules of FlexAgain with a glass of water.
Real Customer Reviews Of FlexAgain
Flex Again has garnered a lot of online support from verified purchasers in a short time. It has a 4.3-star rating on Amazon, with positive reviews on TrustPilot and Reddit. A common theme is that the supplement quickly gives relief and outstanding customer service.
Here are a couple of typical comments from verified Amazon purchasers:
I've been looking for a joint supplement to ease my joint pain forever.
Ever since I had the bike accident, my shoulder has hurt on a daily basis and never goes away. Some friends recommended me to try joint supplements, but I've always been a skeptic.
After looking for the best joint supplements for pain relief after injury, I found this product. Initially, I was thinking of buying a cheaper product, but I hate wasting my money, so I thought it was worth a shot.
A few days in, I can definitely notice the difference. My shoulder still hurts sometimes, but the pain is much less. It also feels like there's more joint mobility when I do shoulder exercises.
So far so good. I strongly recommend trying it out.
Johnny (source)
I purchased this direct from FlexAgain (wasn't available on Amazon) based on positive reviews. I spent two days of research looking for negatives and couldn't find any, so I decided to give it a try. The service is excellent, and orders are received within days of the order. I've noticed a difference since I started using this product vs Move Free that I was previously using. If my experience should change, I'll provide an update.
vt (source)
FlexAgain Alternatives
FlexAgain enters a very competitive joint supplement market. To see how it compares, here are the profiles of a couple of market leaders:
1) Physio Flex Pro
Physio Flex Pro is a natural joint health supplement developed by SRS Nutra. According to their official website, Physio Flex Pro is designed to address joint pain, protect cartilage, lubricate stiff joints, and strengthen joints to prevent injuries. It is priced at $58 for a one-month supply and comes with a 60-day money-back guarantee.
The ingredient profile of Physio Flex Pro includes several well-known joint health ingredients, with the notable absence of collagen and hyaluronic acid. The ingredients are certified as A1-grade active, organic, and free of additives and fillers. While some ingredients, such as MSM and chondroitin sulfate, are underdosed, the overall formula has the potential to make a positive impact.
SRS Nutra's exclusive focus on producing this product suggests a commitment to its quality. However, there is room for improvement, particularly by increasing the dosages of MSM and chondroitin and considering the addition of Omega-3 and hyaluronic acid. The competitive pricing and the 60-day money-back guarantee add to its appeal.
Pros
- Research-backed ingredients
- Athlete endorsed
- 60-day money-back guarantee
Cons
- It does not include omega-3 fatty acids
Physio Flex Pro achieves pharmaceutical strength joint care by hacking natural compounds and complex extraction processes on specialist ingredients...
2) Performance Lab Flex
Flex is a joint supplement produced by Performance Lab, a well-established company with a reputation for transparency and customer service. The company claims that Flex is the world's most advanced daily health supplement with the ability to soothe joint aches and stiffness, offset joint inflammation and protect against free radical damage, lubricate the joints, improve joint mobility and shock absorption, and enhance bone strength.
Performance Lab Flex contains the following five ingredients:
- CurcuWIN® Turmeric: 250mg
- AprèsFlex® Boswellia Serrata: 100mg
- Glucosamine Sulfate 2KCI: 200mg
- Phytodroitin: 100mg
- MSM: 100mg
The turmeric used here is concentrated for better absorption. This ingredient and Boswellia serrata both have a decent amount of research support for their effectiveness as a joint supplement. There is less support for glucosamine, with most studies being done on small subject cohorts. The glucosamine used here is derived from corn, which makes this a vegan-friendly supplement.
Performance Lab Flex can only be purchased from the official Performance Lab website. It costs $49 for a one-month supply, making it pretty cost-effective in the current market.
Pros
- Well priced
- Transparent labelling
- Reputable company
Cons
- A couple of ingredients are underdosed
Performance Lab® Flex ultramodern joint nutrients are curated and combined for active joint demands. Flex soothes and protects achy joints with...
FlexAgain FAQs
Here's a roundup of the most common questions asked online regarding FlexAgain:
How much does FlexAgain cost?
FlexAgain is priced at $69.47 for a one-month supply (160 capsules) on the official website. You can also purchase a 2-month supply for $129.19 or a 3-month supply for $182.01. If you order two or more bottles, you will get free shipping. Your order is also covered by a 90-day money-back guarantee.
Is there a joint supplement that really works?
Yes, there is a joint supplement that really works to relieve joint pain, and FlexAgain is it. Based on the strength of the ingredients, their dosages, and the almost universally positive customer feedback on this product, we believe FlexAgain will relieve joint pain when taken according to instructions.
What are the side effects of FlexAgain?
Most people will not experience any side effects from taking FlexAgain. However, some people may experience digestive problems like bloating, gas, and diarrhea. Several ingredients in FlexAgain may interact with blood-thinning medications when taken at high doses.
Summary Of FlexAgain
FlexAgain is one of the most impressive new supplements that we've come across, regardless of the category. We love the transparency of the company behind the product, which includes a lack of hype.
This joint supplement doesn't need lots of hype; it's packed with research-supported ingredients that are dosed to be effective. Couple that with the excellent service that seems the standard for the FlexAgain guys, and you have a winner!
FlexAgain is the most comprehensive joint health supplement on our list, with a whopping 11 fully dosed ingredients designed to support joint mobility, flexibility and overall health it’s a fantastic choice...
For more options to aid joint health, read the 7 Best Joint Supplements To Alleviate Joint Pain
References
-
Kostoglou-Athanassiou I, Athanassiou L, Athanassiou P. The Effect of Omega-3 Fatty Acids on Rheumatoid Arthritis. Mediterr J Rheumatol. 2020 Jun 30;31(2):190-194. doi: 10.31138/mjr.31.2.190. PMID: 32676556; PMCID: PMC7362115.
-
Connor, E. (2020, September 9). Vitamin D and joint pain. Healthline. https://www.healthline.com/health/vitamin-d-and-joint-pain#takeaway
-
Staff, E. (2020, February 6). Vitamin K shows promise against arthritis. Tufts Health & Nutrition Letter. https://www.nutritionletter.tufts.edu/special-reports/vitamin-k-shows-promise-against-arthritis/
-
Supplement and herb guide for arthritis symptoms . Supplement and Herb Guide for Arthritis Symptoms | Arthritis Foundation. (n.d.). https://www.arthritis.org/health-wellness/treatment/complementary-therapies/supplements-and-vitamins/supplement-and-herb-guide-for-arthritis-symptoms
-
Brien S, Lewith G, Walker A, Hicks SM, Middleton D. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. doi: 10.1093/ecam/neh035. Epub 2004 Oct 6. PMID: 15841258; PMCID: PMC538506.
-
Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016 Aug;19(8):717-29. doi: 10.1089/jmf.2016.3705. PMID: 27533649; PMCID: PMC5003001.
-
Nguyen C, Savouret JF, Widerak M, Corvol MT, Rannou F. Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review. Nutrients. 2017 Jan 6;9(1):45. doi: 10.3390/nu9010045. PMID: 28067817; PMCID: PMC5295089.
-
Yu, G., Xiang, W., Zhang, T.et al. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complement Med Ther 20, 225 (2020). https://doi.org/10.1186/s12906-020-02985-6
Steve Theunissen
Author